Peptic Ulcer Disease

Peptic ulcer disease refers to painful sores in the lining of the stomach or first part of the small intestine, the duodenum. In some cases lower end of esophagus is seen to be affected by Peptic Ulcer Disease. The common site of Peptic Ulcer Disease include-


2.First part of small intestine

3. Lower end of esophagus

Peptic Ulcer Disease is grossly classified as two types- 1. Gastric(Stomach) Ulcer 2. Duodenal Ulcer. In case of gastric ulcer there is severe pain sensation after taking HCL secretion. On the contrary in duodenal ulcer pain is relieved following taking meal. In duodenal ulcer there is pain sensation in empty stomach.

Problem Statement Of Peptic Ulcer Disease

The incidence rates of Peptic Ulcer Disease are more the developing countries than the western countries. The cases of Peptic Ulcer Disease are frequently seen in Indian subcontinent. This disease is more commonly seen in lower sections of people. Male and female can be equally affected by Peptic Ulcer Disease.

Causes Of Peptic Ulcer Disease

Multiple causes are involved in the occurrence of Peptic Ulcer Disease. The main causes are

1. Bacterial infection by Helicobacter pylori.

2. Non-steroidal anti-inflammatory drugs (NSAIDs)

3. Smoking

4. Familial

Other causes include-

-Excessive secretion of pepsin

-Congenital weakness of GIT structural framework

– Irregular taking meal

-Prolonged starvation

Persons with “O” blood group have high tendency to develop Peptic Ulcer Disease.

Symptoms Of Peptic Ulcer Disease

Peptic Ulcer Disease

  • Abdominal Pain: The pain of Peptic Ulcer Disease usually felt in the upper abdomen just below the level of ribs. Sometimes can pain migrate to the back. The pain is burning in nature. Pain is felt one to three hours after meals or in the middle of the night. Pain is relieved by eating, taking antacid or following vomiting.

Other symptoms include

  • Bloating
  • Heartburn
  • Anorexia
  • Nausea or vomiting
  • Hematemesis
Treatment of Peptic Ulcer Disease


The drugs of Peptic Ulcer Disease include-

a). Acid Neutralizer: Ranitidine. Famotidine, Nizatidine

b). Proton Pump Inhibitor: Omeprazole, Pantoprazole, Esomeprazole


a) Avoidance of smoking

b) As far as possible avoid taking NSAIDs

c) Regular taking meal


Operation is not so emergency in Peptic Ulcer Disease. But when after prolog drug therapy condition doesn’t get better or when some part of GI tract becomes narrow then an operation is performed to improve the condition.

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